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Wolfram syndrome is a rare and fatal genetic disorder. Allen Kaasik and colleagues examined the role of the pro- tein wolframin1 in the condition and found a strong mitochondrial involvement. 

Wolfram syndrome is a disorder that affects several systems in the body. Its primary symptoms are diabetes mellitus and optic atrophy; though not guaranteed, other symptoms include diabetes insipidus, sensorineural deafness, neurological and psychiatric dis­ orders, and brain atrophy. Wolfram syn­ drome is estimated to affect around one in half a million people.

Life expectancy for a patient with Wolf­ ram syndrome is around 30 years. Patients usually die from complications related to diabetes mellitus or neuro­ logical problems, such as respiratory failure resulting from brain stem atrophy. 


Molecular biomedicine in Tartu, Estonia